We need people – people like those in TB Alert, who are focused and ambitious and care for people at grass roots in the UK, India and Africa. Dr Lucica Ditiu, Executive Secretary of the Stop TB Partnership
Recurrence of TB after successful drug treatment is a recognised challenge in tuberculosis control. Recurrence can happen as a result of reinfection, or, as scientists at Stanford University have established, through reactivation of dormant TB bacteria ‘hiding’ in bone marrow mesenchymal stem cells.
The remarkable study published in the Science Translational Medicine journal has demonstrated that bone marrow stem cells provide a safe shelter for dormant TB bacteria, even after successful TB treatment. The bacteria are present in a nonreplicating, dormant but viable state, and can get reactivated to cause active TB.
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